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Adenoviral vectors for gene...
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monografia Rebiun18285272 https://catalogo.rebiun.org/rebiun/record/Rebiun18285272 m o d cr bn|---a|cuu 160322s2016 enka ob 000 0 eng d 9780128002766 012800276X 9780128005101 0128005106 CBUC 991034765469706706 UPCT u419259 UNAV 615.8/95 23 Adenoviral vectors for gene therapy Recurso electrónico] edited by David T. Curiel Second edition Londonm UK Academic Press is an imprint of Elsevier 2016 Londonm UK Londonm UK Academic Press is an imprint of Elsevier Text txt rdacontent computer c rdamedia online resource cr rdacarrier Science Direct e-books Descripción basada en el recurso electrónico; tít. tomado del PDF (ScienceDirect, visitado en Marzo 22, 2016) Incluye referencias bibliográficas Front Cover; Adenoviral Vectors for Gene Therapy; Adenoviral Vectors for Gene Therapy; Copyright; Contents; List of Contributors; 1 -- Adenovirus Structure; 1. Historical Perspective on Adenovirus Structure; 2. Hexon Structure and Capsid Packing; 3. Penton Base Structure and Integrin-Binding RGD Loop; 4. Fiber Structure and Receptor Interactions; 5. Atomic Resolution Cryo-Electron Microscopy and X-ray Crystallographic Adenovirus Structures; 6. Hexons in the Atomic Resolution Adenovirus Structures; 7. Conformational Differences of the Penton Base in the Atomic Resolution Adenovirus Structures 8. Alternate Assignments for the Four-Helix Coiled Coil9. Protein IIIa Structure; 10. Protein IX Structure; 11. Core Protein V Structure; 12. Protein VI Structure; 13. Protein VIII Structure; 14. Adenovirus Protease; 15. Concluding Remarks; References; 2 -- Biology of Adenovirus Cell Entry: Receptors, Pathways, Mechanisms; 1. Introduction; 2. Entry Pathways: Impact of Capsid Proteins; 3. Attachment Factors and Signaling Receptors; 3.1 Accessing the CAR; 3.2 Using CD46 in High- and Low-Affinity Modes; 3.3 Desmoglein-2; 3.4 Sialic Acid; 3.5 Heparan Sulfate 3.6 Scavenger Receptors and Other Attachment Factors3.7 Internalization Co-receptors: Integrins; 3.8 Extracellular Factors Influencing Viral Tropism; 3.8.1 Coagulation Factors; 3.8.2 Immunoglobulins and Complement; 3.8.3 Lactoferrin; 3.8.4 Dipalmitoylphosphatidylcholine; 4. Endocytosis; 4.1 Clathrin-Mediated Endocytosis; 4.2 Macropinocytosis; 4.3 Phagocytosis; 4.4 Caveolar Endocytosis; 5. Endosomal Escape; 5.1 Protein VI for Membrane Lysis; 5.2 A New Concept: Hijacking Membrane Repair for Endosome Lysis; 6. Targeting the Nucleus; 6.1 Transport through the Cytoplasm 6.2 Deoxyribonucleic Acid Uncoating and Nuclear Import7. Conclusions and Perspectives; Acknowledgments; References; 3 -- Adenovirus Replication; 1. Introduction; 2. Classification; 3. Adenovirus Genome Organization; 4. Virus Infection; 5. Early Gene Expression; 5.1 Early Region 1A; 5.2 Early Region 1B; 5.3 Early Region 2; 5.4 Early Region 3; 5.5 Early Region 4; 6. Viral DNA Replication; 7. Virus-Associated RNA Genes; 8. Late Gene Expression; 9. Viral DNA Packaging; 10. Conclusion; References; 4 -- Adenoviral Vector Construction 1.2 Adenovirus Vectors2. Cell Lines for Propagating Adenovirus Vectors; 2.1 Propagation of Adenovirus Vectors Encoding Toxic Transgenes for Cancer Gene Therapy; 3. Construction of First-Generation Adenoviral Vectors; 3.1 Early Methods; 3.2 The Two-Plasmid Rescue System; 3.2.1 Development of the Two-Plasmid Rescue System; 3.2.2 Fine-Tuning of the Two-Plasmid Rescue System; 4. Steps Involved in Adenovirus Vector Construction; 4.1 Preparation of Adenovirus Genomic and Shuttle Plasmid DNA for Cotransfection; 4.2 Cotransfection of HEK-293 Cells with Genomic and Shuttle Plasmid Forma de acceso: World Wide Web Curiel, David ed