Descripción del título
Matrix Metalloproteinase In...
Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and\00A0metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. \00A0 The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development
Monografía
monografia Rebiun16869280 https://catalogo.rebiun.org/rebiun/record/Rebiun16869280 cr nn 008mamaa 120404s2012 sz | s |||| 0|eng d 9783034803649 978-3-0348-0364-9 10.1007/978-3-0348-0364-9 doi UR0349184 UPVA 996880975803706 UAM 991007700395204211 PSAN bicssc MED057000 bisacsh 612.8 23 Gupta, Satya Prakash Matrix Metalloproteinase Inhibitors Recurso electrónico-En línea] :] Specificity of Binding and Structure-Activity Relationships edited by Satya Prakash Gupta Basel Springer Basel 2012 Basel Basel Springer Basel X, 285p. 184 illus., 11 illus. in color. digital X, 285p. 184 illus., 11 illus. in color. Experientia Supplementum 1023-294X 103 Biomedical and Life Sciences (Springer-11642) Matrix Metalloproteinases -- Specificity of Binding with Matrix Metalloproteinases -- The Gelatinases and Their Inhibitors: The Structure\2013Activity Relationships -- Advances in Studies on Collagenase Inhibitors -- Hydroxamic Acids as Matrix Metalloproteinase Inhibitors -- Quantitative Structure\2013Activity Relationship Studies on Sulfonamide-Based MMP Inhibitors -- Matrix Metalloproteinase Inhibitors as Investigative Tools in the Pathogenesis and Management of Vascular Disease Accesible sólo para usuarios de la UPV Recurso a texto completo Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and\00A0metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. \00A0 The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development Reproducción electrónica Forma de acceso: Web Medicine Neurosciences Biomedicine Neurosciences SpringerLink (Servicio en línea) Springer eBooks Springer eBooks Printed edition 9783034803632 Experientia Supplementum 1023-294X 103