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The Biochemistry of Retinoi...
The role of vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes, and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems, and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent information explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development, and continued well-being, and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. Volume II is divided into nine chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research
Monografía
monografia Rebiun18473638 https://catalogo.rebiun.org/rebiun/record/Rebiun18473638 cr nn 008mamaa 161109s2016 ne | s |||| 0|eng d 9789402409451 10.1007/978-94-024-0945-1 doi UEM 88289 CBUC 991000823139706708 CBUC 991035721889706706 UPVA 996888453903706 UAM 991007697351104211 CBUC 991010468748306709 CBUC 991010468748306709 UR0401266 MFN bicssc MED107000 bisacsh SCI029000 bisacsh 611.01816 23 The Biochemistry of Retinoid Signaling II Recurso electrónico-En línea] The Physiology of Vitamin A - Uptake, Transport, Metabolism and Signaling edited by Mary Ann Asson-Batres, Cecile Rochette-Egly Dordrecht Springer Netherlands Imprint: Springer 2016 Dordrecht Dordrecht Springer Netherlands Imprint: Springer IX, 263 p. 52 illus., 40 illus. in color. online resource IX, 263 p. 52 illus., 40 illus. in color. Text txt rdacontent computer c rdamedia online resource cr rdacarrier Subcellular Biochemistry 0306-0225 81 Biomedical and Life Sciences (Springer-11642) Preface, Mary Ann Asson-Batres and Cecile Rochette-Egly -- In Memorium -- 1 Carotenoids and Retinoids: Nomenclature, Chemistry, and Analysis, Earl H. Harrison and Robert W. Curley, Jr -- 2 Functions of Intracellular Retinoid Binding-Proteins, Joseph L. Napoli -- 3 Vitamin A Transport and Cell Signaling by the Retinol-Binding Protein Receptor STRA6, Noa Noy -- 4 Vitamin A Absorption, Storage and Mobilization, William S. Blaner, Yang Li, Jason J. Yuen, Seung-Ah Lee, and Robin D. Clugston -- 5 Retinoic Acid Synthesis and Degradation, Natalia Y. Kedishvili -- 6 Cellular Retinoic Acid Binding Proteins: Genomic and Non-Genomic Functions and their Regulation, Li-Na Wei -- 7 Non-Classical Transcriptional Activity of Retinoic Acid, Noa Noy -- 8 Vitamin A as PKC Co-factor and Regulator of Mitochondrial Energetics, Ulrich Hammerling -- 9 Vitamin A and Vision, John C Saari -- Index Accesible sólo para usuarios de la UPV Recurso a texto completo The role of vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes, and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems, and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent information explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development, and continued well-being, and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. Volume II is divided into nine chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research Reproducción electrónica Forma de acceso: Web Medicine Gene expression Nutrition Biochemistry Plant biochemistry Proteins Systems biology Biomedicine Gene Expression Animal Biochemistry Protein Science Nutrition Plant Biochemistry Systems Biology Asson-Batres, Mary Ann. editor Rochette-Egly, Cecile. editor SpringerLink (Servicio en línea) Springer eBooks Springer eBooks Printed edition 9789402409437 Subcellular Biochemistry 0306-0225 81