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Adhesion G Protein-coupled ...
Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function
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monografia Rebiun18285285 https://catalogo.rebiun.org/rebiun/record/Rebiun18285285 cr nn 008mamaa 161110s2016 gw | s |||| 0|eng d 9783319415239 978-3-319-41523-9 10.1007/978-3-319-41523-9 doi CBUC 991035721189706706 UPVA 996888265103706 UAM 991007697336704211 UR0398406 MMG bicssc MED071000 bisacsh 615 23 Adhesion G Protein-coupled Receptors Recurso electrónico-En línea] :] Molecular, Physiological and Pharmacological Principles in Health and Disease edited by Tobias Langenhan, Torsten Schöneberg Cham Springer International Publishing Imprint: Springer 2016 Cham Cham Springer International Publishing Imprint: Springer XIV, 403 p. 68 illus., 67 illus. in color. online resource XIV, 403 p. 68 illus., 67 illus. in color. Text txt rdacontent computer c rdamedia online resource cr rdacarrier Handbook of Experimental Pharmacology 0171-2004 234 Biomedical and Life Sciences (Springer-11642) PART I. Molecular and Pharmacological Properties of Adhesion GPCRs:-Classification, Nomenclature and Structural Aspects of Adhesion GPCRs -- 7TM Domain Structure of Adhesion GPCRs -- Understanding the Structural Basis of Adhesion GPCR Functions.-Control of Adhesion GPCR Function Through Proteolytic Processing.-Tethered Agonism: A Common Activation Mechanism of Adhesion GPCRs -- Versatile Signaling Activity of Adhesion GPCRs -- Adhesion GPCR-Related Protein Networks.-The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans -- PART II: Adhesion GPCRs as Pharmakotargets in Organ Function and Development -- Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors -- Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration -- Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination.-Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs -- Adhesion GPCR Function in Pulmonary Development and Disease.-Adhesion GPCRs as Modulators of Immune Cell Function.-Heart Development, Angiogenesis, and Blood-Brain Barrier Function is Modulated by Adhesion GPCRs.-Adhesion GPCRs in Tumorigenesis Accesible sólo para usuarios de la UPV Recurso a texto completo Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function Reproducción electrónica Forma de acceso: Web Medicine Human genetics Human physiology Pharmacology Medical biochemistry Cell biology Biomedicine Pharmacology/Toxicology Human Physiology Human Genetics Cell Biology Medical Biochemistry Langenhan, Tobias. editor Schöneberg, Torsten. editor SpringerLink (Servicio en línea) Springer eBooks Springer eBooks Printed edition 9783319415215 Handbook of Experimental Pharmacology 0171-2004 234