Descripción del título
GABAB Receptor [edited by G...
An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology
Monografía
monografia Rebiun18365609 https://catalogo.rebiun.org/rebiun/record/Rebiun18365609 cr nn 008mamaa 161219s2016 gw | s |||| 0|eng d 9783319460444 978-3-319-46044-4 10.1007/978-3-319-46044-4 doi CBUC 991035723149706706 UPVA 996893818203706 UAM 991007697162104211 UR0399447 PSAN bicssc MED057000 bisacsh 612.8 23 GABAB Receptor Recurso electrónico-En línea] edited by Giancarlo Colombo Cham Springer International Publishing Imprint: Humana Press 2016 Cham Cham Springer International Publishing Imprint: Humana Press XX, 385 p. 64 illus., 19 illus. in color. online resource XX, 385 p. 64 illus., 19 illus. in color. Text txt rdacontent computer c rdamedia online resource cr rdacarrier The Receptors 29 Biomedical and Life Sciences (Springer-11642) 1. Historical Perspectives on the GABAB Receptor -- Section 1. Chemistry -- 2. Chemistry of GABAB Receptor Ligands: Focus on Agonists and Antagonists -- 3. Chemistry of GABAB Receptor Ligands: Focus on Positive Allosteric Modulators -- Section 2. Molecular Biology, Biochemistry, & Physiology -- 4. Molecular Structure and Trafficking of the GABAB Receptor -- 5. Distribution and Localization of the GABAB Receptor -- 6. Activation Mechanism and Allosteric Properties of the GABAB Receptor -- 7. Modulation of Neurotransmission by the GABAB Receptor -- 8. GABAB Receptor Functions In The Mesolimbic Dopamine System -- Section 3. Pharmacology -- 9. Drug Discrimination Studies for Investigations on the Mechanisms of Action of GABAB Receptor Ligands -- 10. Targeting the GABAB Receptor for the Treatment of Epilepsy -- 11. Targeting the GABAB Receptor for the Treatment of Pain -- 12. Targeting the GABAB Receptor for the Treatment of Psychiatric Disorders -- 13. Targeting the GABAB Receptor for the Treatment of Fragile X Syndrome and Autism Spectrum Disorders -- 14. Targeting the GABAB Receptor for the Treatment of Substance Use Disorder -- 15. Targeting the GABAB Receptor for the Treatment of Alcohol Use Disorder -- 16. Targeting GABAB Receptors for the Treatment of Gastroesophageal Reflux Disease and Chronic Cough -- 17. Baclofen: Therapeutic Use and Potential of the Prototypic GABAB Receptor Agonist -- 18. Allosteric Modulators: The New Generation of GABAB Receptor Ligands -- 19. GABAB Receptor Antagonists as Cognition Enhancers Accesible sólo para usuarios de la UPV Recurso a texto completo An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology Reproducción electrónica Forma de acceso: Web Medicine Neurosciences Neurology Biomedicine Neurosciences Neurology Colombo, Giancarlo editor SpringerLink (Servicio en línea) Springer eBooks Springer eBooks Printed edition 9783319460420 The Receptors 29