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DJ-1/PARK7 Protein [Parkins...
This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinsons disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. .
Monografía
monografia Rebiun22819552 https://catalogo.rebiun.org/rebiun/record/Rebiun22819552 m o d | cr nn 008mamaa 171116s2017 si s 00 0 eng d 9789811065835 9789811065828 9789811065842 9789811349089 10.1007/978-981-10-6583-5 doi UMA.RE MJCL bicssc MED062000 bisacsh 614.5999 23 DJ-1/PARK7 Protein Recurso electrónico] Parkinsons Disease, Cancer and Oxidative Stress-Induced Diseases edited by Hiroyoshi Ariga, Sanae M. M. Iguchi-Ariga Singapore Springer Singapore 2017 Singapore Singapore Springer Singapore Singapore Springer Singapore Imprint: Springer 2017 Singapore Singapore Springer Singapore Imprint: Springer VIII, 222 p. 78 il., 46 il. col VIII, 222 p. 78 il., 46 il. col Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Advances in Experimental Medicine and Biology 1037 Includes bibliographical references at the end of each chapters Preface.-Chapter 1 Introduction/Overview -- Chapter 2 Structural Biology of the DJ-1 Superfamily -- Chapter 3 Expression of DJ-1 in patients with neurodegenerative diseases -- Chapter 4 DJ-1 as an oncogene and its clinical significance -- Chapter 5 Role of DJ-1 in fertilization -- Chapter 6 Anti-oxidative stress function of DJ-1 -- Chapter 7 Ttranscriptional regulation of DJ-1 -- Chapter 8 Regulation of Signal Transduction by DJ-1 -- Chapter 9 Protein repair by DJ-1 from glycation by glyoxal and methylglyoxal -- Chapter 10 DJ-1 as a biomarker of Parkinson's disease -- Chapter 11 Roles of DJ-1 in diabetes mellitus -- Chapter 12 Therapeutic activities of DJ-1 and its binding compounds against neurodegenerative diseases -- Chapter 13 DJ-1 as an oncogene and promising target for cancer chemotherapy. . This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinsons disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. . Oncology Biochemistry Neurosciences Cytology Cancer Research. Biochemistry, general. Neurosciences. Cell Biology. Oncology Biochemistry Neurosciences Cytology Cancer Research Biochemistry, general Cell Biology Ariga, Hiroyoshi ed. lit Iguchi-Ariga, Sanae M. M ed. lit 981-10-6582-9 Advances in Experimental Medicine and Biology 1037