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Neurobiology of Huntington'...
In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this
Monografía
monografia Rebiun28545337 https://catalogo.rebiun.org/rebiun/record/Rebiun28545337 m o d | cr -n--------- 180420s2010 fluaf ob 001 0 eng d 1-138-11662-9 0-429-12225-X 1-4200-0825-0 10.1201/EBK0849390005 doi UPVA 998633874803706 CBUC 991009621456606719 MiAaPQ eng rda pn MiAaPQ MiAaPQ eng Neurobiology of Huntington's disease applications to drug discovery edited by Donald C. Lo and Robert E. Hughes Boca Raton CRC Press/Taylor & Francis Group 2010 Boca Raton Boca Raton CRC Press/Taylor & Francis Group 1 online resource (342 p.) 1 online resource (342 p.) Frontiers in neuroscience Description based upon print version of record Includes bibliographical references and index ch. 1. Huntington's disease : clinical features and routes to therapy / Henry L. Paulson and Roger L. Albin -- ch. 2. Huntington's disease pathogenesis : mechanisms and pathways / Albert R. La Spada, Patrick Weydt, and Victor V. Pineda -- ch. 3. Protein interactions and target discovery in HD / John P. Miller and Robert E. Hughes -- ch. 4. Target validation for Huntington's disease / Seung P. Kwak, James K.T. Wang, and David S. Howland -- ch. 5. High-throughput and high-content screening for Huntington's disease therapeutics / Hemant Varma, Donald C. Lo, and Brent R. Stockwell -- ch. 6. Value of invertebrate genetics and biology to develop neuroprotective and preventive medicine in Huntington's disease / Christian Neri -- ch. 7. Mouse models for validating preclinical candidates for HD / X. William Yang and Michelle Gray -- ch. 8. Pharmaceutical development for HD / Richard J. Morse ... [et al.] -- ch. 9. RNA and DNA-based therapies for Huntington's disease / Meghan Sass and Neil Aronin -- ch. 10. Recombinant intrabodies as molecular tools and potential therapeutics for Huntington's disease / Ali Khoshnan ... [et al.] -- ch. 11. Biomarkers to enable the development of neuroprotective therapies for Huntington's disease / Steven M. Hersch and H. Diana Rosas -- ch. 12. Huntington disease : clinical experimental therapeutics / Ray Dorsey and Ira Shoulson In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this English Lo, Donald C. Hughes, Robert E. Ph.D. 1-322-61357-5 0-8493-9000-1 Frontiers in neuroscience (Boca Raton, Fla.)