Descripción del título
Cell engineering. edited by...
Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy
Monografía
monografia Rebiun36080537 https://catalogo.rebiun.org/rebiun/record/Rebiun36080537 m o d | cr -n--------- 110608s2011 ne ad ob 001 0 eng d 94-007-1257-X 10.1007/978-94-007-1257-7 doi CBUC 991010404822106709 UPVA 996875430003706 UAM 991007700007004211 MiAaPQ eng rda pn MiAaPQ MiAaPQ eng MBGR bicssc MED000000 bisacsh 571.9/67 616.0798 Cell engineering. Vol. 7 Antibody expression and production edited by Mohamed Al-Rubeai 1st ed. 2011 Dordrecht [The Netherlands] Springer 2011 Dordrecht [The Netherlands] Dordrecht [The Netherlands] Springer 1 online resource (348 p.) 1 online resource (348 p.) Text txt computer c online resource cr Cell engineering 1389-6946 Description based upon print version of record Includes bibliographical references and index 1 Expression of antibody in mammalian cells, Thomas Jostock -- 2 Bioreactor systems for producing antibody from mammalian cells, Darrin Kuystermans and Mohamed Al-Rubeai -- 3 Production of antibody in insect cells, Hideki Yamaji -- 4 Production of monoclonal antibodies in glycoengineered Pichia pastoris, Dongxing Zhu, Thomas Linden and Thomas Potgieter -- 5 Production of antibodies in Hansenula polymorpha, Georg Melmer, Stephan Hellwig, Grit Hehmann and Ulrike Dahlems -- 6 Expression of antibody in transgenic avians, Yoshinori Kawabe and Masamichi Kamihira -- 7 Production of antibodies in plants, Alejandro Sarrion-Perdigones, Paloma Juarez, Antonio Granell and Diego Orzaez -- 8 Production of antibody fab fragments in Escherichia coli, Hiroshi Tachibana and Masataka Takekoshi -- 9 Intrabody expression in mammalian cells, Silvia Biocca -- 10 Engineering of antibodies for cancer therapy, Lisa E. Goldsmith and Matthew K. Robinson -- 11 Recombinant bispecific antibodies for cancer therapy, Dafne Muller and Roland Kontermann -- 12 The role of glycosylation in therapeutic antibodies, Maureen Spearman, Ben Dionne and Mike Butler -- 13 Quality issues arising from post-translational modification of recombinant antibodies, Raymond Tyther and Nigel Jenkins -- 14 Purification of antibody, XueJun Han, Arther Hewig and Ganesh Vedantham -- Index Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy English Immunoglobulins Al-Rubeai, Mohamed 1948-) Cell Engineering (CKB)2660000000008908 94-007-3613-4 94-007-1256-1 Cell engineering