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Cancer stem cells in solid ...
The "cancer stem cell" hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific "niche"/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology
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monografia Rebiun22085305 https://catalogo.rebiun.org/rebiun/record/Rebiun22085305 m o d cr cn||||||||| 110930s2011 nyua ob 001 0 eng d 759159051 771215915 778312249 816875369 823130884 1058312089 1087350325 9781617792465 electronic bk.) 1617792462 electronic bk.) 1283354098 9781283354097 9781617792458 1617792454 10.1007/978-1-61779-246-5 doi AU@ 000048774683 AU@ 000057999456 AU@ 000060504369 NZ1 13935259 978-1-61779-245-8 Springer http://www.springerlink.com GW5XE eng pn GW5XE E7B EBLCP OCLCQ OCLCF OCLCQ IDEBK OCLCQ VGM OCLCQ ESU IOG MERUC CEF U3W AU@ OCLCQ WYU YOU MFGC bicssc 616.99/4071 23 Cancer stem cells in solid tumors Alison L. Allan, editor New York Springer ©2011 New York New York Springer 1 online resource (xvii, 475 pages) illustrations (some color) 1 online resource (xvii, 475 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Stem cell biology and regenerative medicine Includes bibliographical references and index pt. 1. Introduction to cancer stem cells -- pt. 2. Cancer stem cells in solid tumors -- pt. 3. Cancer stem cells gene expression and mechanisms : convergence of embryonic and tumorigenic signaling pathways -- pt. 4. Model systems for studying cancer stem cell biology and therapeutic development -- pt. 5. Clinical and therapeutic implications of cancer stem cells -- pt. 6. Final thoughts The "cancer stem cell" hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific "niche"/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology English Cancer cells Cáncer- Molecular aspects Stem cells Cancer cells. Cáncer- Molecular aspects. Stem cells. Electronic books Allan, Alison L. Print version Cancer stem cells in solid tumors. New York : Springer, 2011 (DLC) 2011932988 Stem cell biology and regenerative medicine