Descripción del título
Matrix metalloproteinase in...
Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and¡metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. ¡ The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development
Monografía
monografia Rebiun24007259 https://catalogo.rebiun.org/rebiun/record/Rebiun24007259 m o d cr cnu---unuuu 120418s2012 sz ob 001 0 eng d 797328963 798207941 801364483 808620904 817092345 857254116 978062560 985038751 990677314 1005782043 1026434615 1058623476 9783034803649 electronic bk.) 3034803648 electronic bk.) 9783034803632 303480363X 1280786744 9781280786747 9786613697134 6613697133 10.1007/978-3-0348-0364-9 doi CHBIS 007312319 CHBIS 009892044 CHVBK 182535630 CHVBK 199072639 DEBSZ 44281948X NZ1 14536814 GW5XE eng pn GW5XE ZMC COO YDXCP OCLCQ E7B UTO OCLCO N$T MEAUC OCLCF OCLCQ CHVBK EBLCP CDX IDEBK DEBSZ OCLCQ OCLCO TXI OCLCQ CNUTO VT2 OCLCQ ESU IOG REB OCLCO OCLCQ OCLCO CEF OCLCQ U3W OCLCO WYU OCLCA YOU TKN OCLCQ LEAUB DKC CNTRU OCLCQ UKAHL OCLCQ AU@ MED 060000 bisacsh PSAN bicssc RM lcco 572/.7 23 Matrix metalloproteinase inhibitors specificity of binding and structure-activity relationships Satya Prakash Gupta, editor Basel New York Springer ©2012 Basel New York Basel New York Springer 1 online resource (x, 285 pages) 1 online resource (x, 285 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Experientia supplementum 1023-294X v. 103 Includes bibliographical references and index Matrix Metalloproteinases Viola Vargová, Marek Pytliak and Viola Mechírová. -- Specificity of Binding with Matrix Metalloproteinases Satya P. Gupta and Vaishali M. Patil. -- The Gelatinases and Their Inhibitors: The Structure-Activity Relationships Snehasikta Swarnakar, Amartya Mishra and Susri Ray Chaudhuri (Guha). -- Advances in Studies on Collagenase Inhibitors Mange Ram Yadav, Prashant Revan Murumkar and Vishal Prakash Zambre. -- Hydroxamic Acids as Matrix Metalloproteinase Inhibitors Rajeshwar P. Verma. -- Quantitative Structure-Activity Relationship Studies on Sulfonamide-Based MMP Inhibitors Vaishali M. Patil and Satya P. Gupta. -- Matrix Metalloproteinase Inhibitors as Investigative Tools in the Pathogenesis and Management of Vascular Disease Mina M. Benjamin and Raouf A. Khalil Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and¡metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. ¡ The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development English Metalloproteinases- Inhibitors Extracellular Matrix Proteins Matrix Metalloproteinases MEDICAL- Nutrition. Metalloproteinases- Inhibitors. Matrixproteine. Metalloproteinaseninhibitor. Medicine Neurosciences Biomedicine Electronic books Gupta, Satya Prakash Printed edition 9783034803632 Experientia. Supplementum v. 103