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Design and analysis of DNA ...
This book is targeted to biologists with limited statistical background and to statisticians and computer scientists interested in being effective collaborators on multi-disciplinary DNA microarray projects. State-of-the-art analysis methods are presented with minimal mathematical notation and a focus on concepts. This book is unique because it is authored by statisticians at the National Cancer Institute who are actively involved in the application of microarray technology. Many laboratories are not equipped to effectively design and analyze studies that take advantage of the promise of microarrays. Many of the software packages available to biologists were developed without involvement of statisticians experienced in such studies and contain tools that may not be optimal for particular applications. This book provides a sound preparation for designing microarray studies that have clear objectives, and for selecting analysis tools and strategies that provide clear and valid answers. The book offers an in depth understanding of the design and analysis of experiments utilizing microarrays and should benefit scientists regardless of what software packages they prefer. In order to provide all readers with hands on experience in data analysis, it includes an Appendix tutorial on the use of BRB-ArrayTools and step by step analyses of several major datasets using this software which is freely available from the National Cancer Institute for non-commercial use. The authors are current or former members of the Biometric Research Branch at the National Cancer Institute. They have collaborated on major biomedical studies utilizing microarrays and in the development of statistical methodology for the design and analysis of microarray investigations. Dr. Simon, chief of the branch, is also the architect of BRB-ArrayTools
Monografía
monografia Rebiun25324526 https://catalogo.rebiun.org/rebiun/record/Rebiun25324526 m o d cr cnu|||unuuu 041126s2003 nyua ob 001 0 eng d GBA441202 bnb 133158238 149310100 320965092 517825920 614856428 647512700 819845998 874207883 923697539 1035659125 1040686432 1044089651 1056295861 1058030030 1078862822 1086476088 1113744589 0387218661 electronic bk.) 9780387218663 electronic bk.) 6610188130 9786610188130 0387001352 9780387001357 10.1007/b97583 doi AU@ 000051745486 NZ1 14977879 NZ1 15296609 N$T eng pn N$T OCLCQ YDXCP OCLCQ OCLCG OCLCQ OCLCO UAB IDEBK CNTRU OKU CASUM E7B OCLCQ GW5XE OCLCF OCLCQ UA@ OCLCQ SLY EBLCP OCLCQ OCLCO OCLCA STF OCLCO OCLCQ CEF U3W OCLCQ AU@ CANPU TKN OCLCO OCLCQ LEAUB OCLCQ UKBTH OCLCQ OCLCA OCLCQ OCLCA SCI 029000 bisacsh MJCL bicssc MJCL thema 572.8/65 22 Design and analysis of DNA microarray investigations Richard M. Simon [and others] New York Springer 2003 New York New York Springer 1 online resource (x, 199 pages) illustrations 1 online resource (x, 199 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Statistics for biology and health Includes bibliographical references and index DNA Microarray Technology -- Design of DNA Microarray Experiments -- Image Analysis -- Quality Control -- Array Normalization -- Class Comparison -- Class Prediction -- Class Discovery This book is targeted to biologists with limited statistical background and to statisticians and computer scientists interested in being effective collaborators on multi-disciplinary DNA microarray projects. State-of-the-art analysis methods are presented with minimal mathematical notation and a focus on concepts. This book is unique because it is authored by statisticians at the National Cancer Institute who are actively involved in the application of microarray technology. Many laboratories are not equipped to effectively design and analyze studies that take advantage of the promise of microarrays. Many of the software packages available to biologists were developed without involvement of statisticians experienced in such studies and contain tools that may not be optimal for particular applications. This book provides a sound preparation for designing microarray studies that have clear objectives, and for selecting analysis tools and strategies that provide clear and valid answers. The book offers an in depth understanding of the design and analysis of experiments utilizing microarrays and should benefit scientists regardless of what software packages they prefer. In order to provide all readers with hands on experience in data analysis, it includes an Appendix tutorial on the use of BRB-ArrayTools and step by step analyses of several major datasets using this software which is freely available from the National Cancer Institute for non-commercial use. The authors are current or former members of the Biometric Research Branch at the National Cancer Institute. They have collaborated on major biomedical studies utilizing microarrays and in the development of statistical methodology for the design and analysis of microarray investigations. Dr. Simon, chief of the branch, is also the architect of BRB-ArrayTools English Micromatrices de ADN- Statistical methods Oligonucleotide Array Sequence Analysis- methods Data Interpretation, Statistical Research Design SCIENCE- Life Sciences- Genetics & Genomics Micromatrices de ADN- Statistical methods Electronic books Simon, Richard M. 1943-) Print version Design and analysis of DNA microarray investigations. New York : Springer, 2003 0387001352 (DLC) 2003054790 (OCoLC)52388053 Statistics for biology and health