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Systemic delivery technolog...
This book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each. The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will be required for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases. Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research
Monografía
monografia Rebiun27148719 https://catalogo.rebiun.org/rebiun/record/Rebiun27148719 m o d cr un|---aucuu 201107s2020 sz o 000 0 eng d 1201225465 1224379356 1225362428 9783030544904 electronic bk.) 3030544907 electronic bk.) 3030544893 9783030544898 10.1007/978-3-030-54490-4 doi AU@ 000068144223 UPNA0524640 CBUC 991004740639706706 UR0511975 UPVA 997151520003706 UAM 991007983980004211 UCAR 991008172523604213 EBLCP eng EBLCP YDX GW5XE OCLCO SFB UKAHL OCLCF TDCW bicssc MED072000 bisacsh TDC thema 615/.6 23 Systemic delivery technologies in anti-aging medicine methods and applications Wing-Fu Lai, editor Cham Springer 2020 Cham Cham Springer 1 online resource (513 p.). 1 online resource (513 p.). Text txt rdacontent computer c rdamedia online resource cr rdacarrier Healthy Ageing and Longevity v.13 Description based upon print version of record Preface -- Part I: Fundamentals of Systemic Delivery -- Anti-aging medicine: new concepts and intervention development,- Roles of systemic delivery in the development of anti-aging therapies -- Pharmacokinetics and pharmacodynamics in drug delivery -- Physiological, biochemical, and chemical barriers to systemic delivery -- Partt II: Development of Delivery Technologies for Systemic Delivery -- Use of prodrugs for systemic delivery in anti-aging medicine -- Use of physical methods for systemic delivery in anti-aging medicine -- Use of viral systems for systemic delivery in anti-aging medicine -- Use of non-viral biological systems for systemic delivery in anti-aging medicine -- Use of lipid-based systems for systemic delivery in anti-aging medicine -- Use of polymeric systems for systemic delivery in anti-aging medicine -- Use of inorganic nanoparticles for systemic delivery in anti-aging medicine -- Part III: Practical Considerations in Intervention Execution -- Strategies in carrier design to enhance systemic delivery -- Characterization techniques for studying the properties of the carriers -- In vivo assessment of the efficiency of systemic delivery in anti-aging medicine -- Selection of administration routes for systemic delivery in anti-aging medicine -- Intellectual property and regulatory issues in drug delivery research -- Index This book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each. The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will be required for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases. Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research Drug delivery systems Aging- Prevention Biology- Technique. Biomedical materials. Medicine. Pharmaceutical technology. Electronic books Lai, Wing-Fu Print version Lai, Wing-Fu. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications Cham : Springer International Publishing AG,c2020 9783030544898 Healthy ageing and longevity v. 13