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Adeno-associated virus (AAV...
"Viral vectors have been the favored delivery vehicle for gene therapy in recent years. Adeno-associated virus has become a candidate of great interest because of its biological properties which include site specific integration in human chromosome 19." "The subject of this book is the use of adeno-associated virus as a new viral vector for gene therapy. AAV vectors can be used to deliver foreign DNA to mammalian cells with the goal of curing genetic diseases and allied conditions. The non-pathogenicity and site specific integration of AAV via a non-homologous recombination event into human chromosome 19 make this virus a very attractive vector. Data from in vitro and in vivo experiments are presented and discussed including recent studies with hematopoietic stem cells and non-dividing cells." "Various protocols for preparing recombinant AAV vectors and their intracellular delivery are also extensively discussed. The first trial of AAV as vector for human gene therapy was conducted in late 1995."--BOOK JACKET
Monografía
monografia Rebiun29202061 https://catalogo.rebiun.org/rebiun/record/Rebiun29202061 m o d cr cnu---unuuu 211001s1996 gw a ob 001 0 eng d 840300885 934992652 936315782 1012433681 1016349712 9783642802072 electronic bk.) 3642802079 electronic bk.) 9783540610762 3540610766 9783642802096 print) 3642802095 print) 10.1007/978-3-642-80207-2 doi AU@ 000051654852 NZ1 15003620 NZ1 15305936 N$T eng rda pn N$T OCLCO I9W UV0 GW5XE OCLCF UA@ COO EBLCP UAB AU@ LEAUB OCLCO X380 X300 616.9041 23 35.73 bcl Adeno-associated virus (AAV) vectors in gene therapy edited by K.I. Berns and C. Giraud Berlin New York Springer 1996 Berlin New York Berlin New York Springer 1 online resource (vi, 173 pages) illustrations 1 online resource (vi, 173 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier Current topics in microbiology and immunology 0070-217X 218 Includes bibliographical references and index Biology of adeno-associated virus / K.I. Berns -- The roles of AAV rep proteins in gene expression and targeted integration / J.A. Chiorini -- Packaging systems for adeno-associated virus vectors / J.P. Thrempe -- The challenges of recombinant adeno-associated virus manufacturing: alternative use of adeno-associated virus plasmid/lipsome complexes for gene therapy applications / J.S. Lebkowski -- Adeno-associated virus vectors for gene therapy of the hematopoietic system / S. Chatterjee -- Adeno-associated virus vectors for gene transfer into erythroid cells / D.M. McCarty -- Adeno-associated virus 2-mediated transduction and erythroid lineage-specific expression in human hematopoietic progenitor cells / A. Srivastava -- Development of adeno-associated virus vectors for gene therapy of cystic fibrosis / B.J. Carter -- Adeno-associated virus-based vectors as antivirals / K.K. Wong "Viral vectors have been the favored delivery vehicle for gene therapy in recent years. Adeno-associated virus has become a candidate of great interest because of its biological properties which include site specific integration in human chromosome 19." "The subject of this book is the use of adeno-associated virus as a new viral vector for gene therapy. AAV vectors can be used to deliver foreign DNA to mammalian cells with the goal of curing genetic diseases and allied conditions. The non-pathogenicity and site specific integration of AAV via a non-homologous recombination event into human chromosome 19 make this virus a very attractive vector. Data from in vitro and in vivo experiments are presented and discussed including recent studies with hematopoietic stem cells and non-dividing cells." "Various protocols for preparing recombinant AAV vectors and their intracellular delivery are also extensively discussed. The first trial of AAV as vector for human gene therapy was conducted in late 1995."--BOOK JACKET Gene therapy Adenoviruses Genetic Therapy- methods Chromosomes, Human, Pair 19 Dependovirus Genes, Viral Genetic Vectors Adenoviruses. Gene therapy. Thérapie génique. Virus à ADN. Vecteurs génétiques. Chromosomes humains de la paire 19. Gènes viraux. Dependovirus. Adenovirussen. Gentherapie. Virus à ADN. Thérapie génique. Vecteurs de clonage. Adenoviridae. Fulltext Internet Resources Electronic books Berns, Kenneth I. 1938-) Giraud, C. Print version Adeno-associated virus (AAV) vectors in gene therapy. Berlin ; New York : Springer, 1996 9783540610762 (DLC) 15012910 (OCoLC)35335471 Current topics in microbiology and immunology 218