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Current Advances in Osteosa...
Current Advances in Osteosarcoma summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in this field over the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and is the most common histological form of bone cancer. Osteosarcoma accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. In order to improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. This volume will provide a comprehensive review of these new discoveries in one singular text, which will help move the field forward
Monografía
monografia Rebiun36107325 https://catalogo.rebiun.org/rebiun/record/Rebiun36107325 m o d | cr -n--------- 140612s2014 gw s 00 0 eng d 9783319048437 9783319048444 9783319048420 9783319344591 10.1007/978-3-319-04843-7 doi UMA.RE eng MJCL bicssc MED062000 bisacsh 616.99 616.99/471 616.99471 Current Advances in Osteosarcoma Recurso electrónico] edited by Eugenie S. Kleinerman, M.D. Cham Springer International Publishing 2014 Cham Cham Springer International Publishing Cham Springer International Publishing Imprint: Springer 2014 Cham Cham Springer International Publishing Imprint: Springer XII, 359 p. 65 il., 54 il. col XII, 359 p. 65 il., 54 il. col Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Advances in Experimental Medicine and Biology 804 Description based upon print version of record Includes bibliographical references and index Historical Perspective on the Introduction and Use of Chemotherapy for the Treatment of Osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: Not Just the Usual Suspects -- Understanding the Role of Notch in Osteosarcoma -- Developmental Pathways Highjacked by Osteosarcoma -- MicroRNAs in Osteosarcomagenesis -- RECQ DNA Helicases and Osteosarcoma -- Autophagy in Osteosarcoma -- HER-2 Involvement in Osteosarcoma -- Role of Ezrin in Osteosarcoma Metastasis -- Participation of the Fas/FasL Signaling Pathway and the Lung Microenvironment in the Development of Osteosarcoma Lung Metastases -- Zebrafish as a Model for Human Osteosarcoma -- Using Canine Osteosarcoma as a Model to Assess Efficacy of Novel Therapies: Can Old Dogs Teach Us New Tricks? -- Oncolytic Viruses for Potential Osteosarcoma Therapy -- IL-11R(Sa(B: A Novel Target for the Treatment of Osteosarcoma -- Bone-seeking Radiopharmaceuticals as Targeted Agents of Osteosarcoma: Samarium-153-EDTMP and Radium-223 -- Muramyl Tripeptide-phophatidyl Ethanolamine Encapsulated in Lipomes (L-MTP-PE) in the Treatment of Osteosarcoma -- Genetically Modified T-cell Therapy for Osteosarcoma -- Natural Killer Cells for Osteosarcoma Current Advances in Osteosarcoma summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in this field over the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and is the most common histological form of bone cancer. Osteosarcoma accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. In order to improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. This volume will provide a comprehensive review of these new discoveries in one singular text, which will help move the field forward English Oncology Microbiology Cytology Pediatrics Cancer Research. Medical Microbiology. Cell Biology. Pediatrics. Oncology Microbiology Cytology Pediatrics Cancer Research Medical Microbiology Cell Biology Pediatrics Kleinerman, M.D., Eugenie S ed. lit 1-322-13422-7 3-319-04842-2 Advances in Experimental Medicine and Biology 804