Descripción del título
I Domain Integrins [edited ...
The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins
Monografía
monografia Rebiun36221694 https://catalogo.rebiun.org/rebiun/record/Rebiun36221694 m o d | cr#-n--------- 140714s2014 ne s 00 0 eng d 9789401791533 9789401791540 9789401791526 9789402402902 10.1007/978-94-017-9153-3 doi UMA.RE eng MBGR bicssc MED000000 bisacsh 572.68 I Domain Integrins Recurso electrónico] edited by Donald Gullberg Dordrecht Springer Netherlands 2014 Dordrecht Dordrecht Springer Netherlands Dordrecht Springer Netherlands Imprint: Springer 2014 Dordrecht Dordrecht Springer Netherlands Imprint: Springer XIV, 179 p. 50 il., 32 il. col XIV, 179 p. 50 il., 32 il. col Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Advances in Experimental Medicine and Biology 819 Description based upon print version of record Includes bibliographical references and index Preface -- 1 Evolution of integrin I domains -- 2 Integrin a1b1 -- 3 Integrin a2b1 -- 4 Integrin a10b1- a collagen receptor critical in skeletal development -- 5 Integrin a11b1 - a major collagen receptor on fibroblastic cells -- 6 Regulation of integrin activity by phosphorylation -- 7 Integrin aEb7:molecular features and functional significance in the immune system -- 8 Structural aspects of integrins -- 9 Integrin recognition motifs in the human collagens -- 10 Cellular signalling by collagen-binding integrins -- 11 The therapeutic potential of I-domain integrins -- Index The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins English Medicine Life sciences Medical genetics Biochemistry Biomedicine general. Life Sciences, general. Gene Function. Medical Biochemistry. Medicine Life sciences Medical genetics Biochemistry Biomedicine general Life Sciences, general Gene Function Medical Biochemistry Gullberg, Donald ed. lit 1-322-47752-3 94-017-9152-X Advances in Experimental Medicine and Biology 819