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Central nervous system dise...
In Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic, prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases, as well as their advantages and limitations. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies
Monografía
monografia Rebiun37022035 https://catalogo.rebiun.org/rebiun/record/Rebiun37022035 m o d cr un||||a|a|| 100824s2000 njua ob 001 0 eng d 50783979 174132128 607406381 1001509435 1012479277 1029285502 1078857426 1086566759 1165400324 0585425299 electronic bk.) 9780585425290 electronic bk.) 9781592596911 electronic bk.) 1592596916 electronic bk.) 9781617371523 print) 1617371521 print) 089603724X acid-free paper) 9780896037243 acid-free paper) 10.1007/978-1-59259-691-1 doi AU@ 000056812461 NZ1 15183244 AU@ 000077592784 OCLCE eng pn OCLCE N$T YDXCP E7B CNTRU IDEBK OCLCQ NUI GW5XE OCLCQ COO OCLCQ UAB OCLCO OCLCA INARC OCLCQ AU@ OCLCO OCLCA CANPU TKN OCLCQ LEAUB OCLCF OCLCA OCLCQ OCLCA OCLCQ OCLCO OCLCQ OCLCO OCLCL OCLCQ dlr HEA 039110 bisacsh MED 056000 bisacsh PSAN bicssc PSAN thema 616.8/0427 21 YG 1700 rvk Central nervous system diseases innovative animal models from lab to clinic edited by Dwaine F. Emerich, Reginald L. Dean III, Paul R. Sanberg Totowa, N.J. Humana Press 2000 Totowa, N.J. Totowa, N.J. Humana Press 1 online resource (xv, 512 pages) illustrations 1 online resource (xv, 512 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF Contemporary neuroscience Includes bibliographical references and index 1 -- The Cholinergic Hypothesis a Generation Later: Perspectives Gained on the Use and Integration of Animal Models -- 2 -- Patterns of Cognitive Decline in the Aged Rhesus Monkey -- 3 -- Cholinergic Lesions as a Model of Alzheimer's Disease: Effects of Nerve Growth Factor -- 4 -- The Immunolesioned Animal as a Model of Transmitter Dysfunction -- 5 -- An Intracerebral Tumor Necrosis Factor-? Infusion Model for Inflammation in Alzheimer's Disease -- 6 -- The Senescence-Accelerated Mouse as a Possible Animal Model of Senile Dementia -- 7 -- Transgenic Mice Overexpressing Presenilin cDNAs: Phenotype and Utility in the Modeling of Alzheimer's Disease -- 8 -- Intervention Strategies for Degeneration of Dopamine Neurons in Parkinsonism: Optimizing Behavioral Assessment of Outcome -- 9 -- Development of Behavioral Outcome Measures for Preclinical Parkinson's Research -- 10 -- Behavioral Assessment in the Unilateral Dopamine-Depleted Marmoset -- 11 -- Molecules for Neuroprotection and Regeneration in Animal Models of Parkinson's Disease -- 12 -- Antisense Knockdown of Dopamine Receptors -- 13 -- Is Trophic Factor Gene Disruption a 'Knockout' Model for Parkinson's Disease? -- 14 -- Operant Analysis of Striatal Dysfunction -- 15 -- Intrastriatal Injections of Quinolinic Acid as a Model for Developing Neuroprotective Strategies in Huntington's Disease -- 16 -- Systemic Administration of 3-Nitropropionic Acid: A New Model of Huntington's Disease in Rat -- 17 -- Replicating Huntington Disease's Phenotype in Nonhuman Primates -- 18 -- Transgenic Mouse Models of Huntington's Disease -- 19 -- Rigid Indentation Models of Traumatic Brain Injury in the Rat -- 20 -- Rodent Ischemia Models of Embolism and Ligation of the Middle Cerebral Artery: Clinical Relevance to Treatment Strategies of Stroke -- 21 -- A Primate Model of Hypertensive Cerebrovascular Disease -- 22 -- Nictotinic Therapeutics for Tourette Syndrome and Other Neuropsychiatric Disorders: From Laboratory to Clinic -- 23 -- Neural Grafting for Parkinson's and Huntington's Disease -- 24 -- Future Prospects of Gene Therapy for Treating CNS Diseases Use copy. Restrictions unspecified star. MiAaHDL In Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic, prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases, as well as their advantages and limitations. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies Electronic reproduction. [Place of publication not identified] HathiTrust Digital Library 2010. MiAaHDL Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL Central nervous system- Diseases- Animal models Biological models Alzheimer Disease- physiopathology Aging- physiology Huntington Disease- physiopathology Models, Biological Parkinson Disease- physiopathology Système nerveux central- Maladies- Modèles animaux Modèles biologiques HEALTH & FITNESS- Diseases- Nervous System (incl. Brain) MEDICAL- Neurology. Neurosciences. Tiermodell. Altersphysiologie. Alzheimerkrankheit. Huntington-Chorea. Parkinson-Krankheit. Pathophysiologie. Zentralnervensystem. Krankheit. Emerich, Dwaine F. Dean, Reginald L. Sanberg, Paul R. Print version Central nervous system diseases. Totowa, N.J. : Humana Press, 2000 (DLC) 99025833 (OCoLC)41096195 Contemporary neuroscience