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Cerebral ischemia : molecul...
In Cerebral Ischemia: Molecular and Cellular Pathphysiology, Wolfgang Walz and a panel of leading authorities illuminate those cellular and molecular mechanisms brought into play during a stroke that lead to neuronal dysfunction. Such damaging factors as spreading depression waves and postischemic depolarization, cell swelling, calcium overload, and oxygen radicals leading to necrosis and apoptosis are described in detail. Also examined are the body's repair mechanisms involving altered gene expression that lead to trophic factor production and heat shock protein synthesis, as well as to astrogliosis and microgliosis. All factors are presented in relation to their therapeutic value and the possible treatment approaches that evolve from their interactions. Cerebral Ischemia: Molecular and Cellular Pathophysiology offers clinicians, interested practitioners, and experimentalists alike a systematic evaluation of all the major biological systems that contribute to brain dysfunction after a vascular accident. Its unique focus on mechanisms and gene expression also provides fresh and powerful insights into the many novel therapeutic strategies and agents for stroke management emerging today
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monografia Rebiun22089147 https://catalogo.rebiun.org/rebiun/record/Rebiun22089147 m o d cr bn||||||abp cr bn||||||ada 100414s1999 njua ob 001 0 eng d 646733686 945916698 968659077 1001479361 1012468345 1016286082 9781592594795 electronic bk.) 1592594794 electronic bk.) 9781475747355 print) 1475747357 print) 0896035409 acid-free paper) 9780896035409 acid-free paper) 10.1007/978-1-59259-479-5 doi NZ1 15183238 AU@ 000057638603 OCLCE eng pn OCLCE OCLCQ NUI GW5XE OCLCQ OCLCF COO OCLCQ EBLCP OCLCQ YDX UAB OCLCA OCLCQ AU@ OCLCO OCLCA dlr 616.8/1 21 Cerebral ischemia molecular and cellular pathophysiology edited by Wolfgang Walz Totowa, N.J. Humana Press ©1999 Totowa, N.J. Totowa, N.J. Humana Press 1 online resource (ix, 278 pages) illustrations 1 online resource (ix, 278 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier Contemporary neuroscience Includes bibliographical references and index Ch. 1. Mechanisms of cerebral ischemic damage-- Ch. 2. Spreading depression waves as mediators of secondary injury and protective mechanisms-- Ch. 3. Cell swelling in cerebral ischemia-- Ch. 4. Calcium overload-- Ch. 5. Oxygen redicals-- Ch. 6. Mechanisms of neuroprotective cytokines: pleiotrophic effects of TNF[alpha] and TGF[beta] on brain injury-- Ch. 7. Reprogramming of gene expression after ischemia-- Ch. 8. Neurons: necrotic vs apoptotic changes-- Ch. 9. Reactive astrogliosis in the injured and postischemic brain-- Ch. 10. Activated and phagocytic microglia Use copy. Restrictions unspecified star. MiAaHDL In Cerebral Ischemia: Molecular and Cellular Pathphysiology, Wolfgang Walz and a panel of leading authorities illuminate those cellular and molecular mechanisms brought into play during a stroke that lead to neuronal dysfunction. Such damaging factors as spreading depression waves and postischemic depolarization, cell swelling, calcium overload, and oxygen radicals leading to necrosis and apoptosis are described in detail. Also examined are the body's repair mechanisms involving altered gene expression that lead to trophic factor production and heat shock protein synthesis, as well as to astrogliosis and microgliosis. All factors are presented in relation to their therapeutic value and the possible treatment approaches that evolve from their interactions. Cerebral Ischemia: Molecular and Cellular Pathophysiology offers clinicians, interested practitioners, and experimentalists alike a systematic evaluation of all the major biological systems that contribute to brain dysfunction after a vascular accident. Its unique focus on mechanisms and gene expression also provides fresh and powerful insights into the many novel therapeutic strategies and agents for stroke management emerging today Electronic reproduction. [S.l.] HathiTrust Digital Library 2010. MiAaHDL Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL Cerebral ischemia- Pathophysiology Cerebral ischemia- Pathophysiology. Brain Ischemia- physiopathology Electronic books Walz, Wolfgang Print version Cerebral ischemia. Totowa, N.J. : Humana Press, ©1999 (DLC) 98032443 (OCoLC)40489062 Contemporary neuroscience