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Arrestins - Pharmacology an...

Arrestins - Pharmacology and Therapeutic Potential

Gurevich, Vsevolod V

Springer

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners

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Medicine Gene therapy Pharmacology Biochemistry Proteins Cell physiology Biomedicine Pharmacology/Toxicology Biochemistry, general Protein Structure Gene Therapy Cell Physiology Receptors

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monografia Rebiun17471752 https://catalogo.rebiun.org/rebiun/record/Rebiun17471752 131128s2014 gw | s |||| 0|eng d 9783642411991 978-3-642-41199-1 9783642411984 10.1007/978-3-642-41199-1. doi UPNA0451643 UMA.RE Arrestins - Pharmacology and Therapeutic Potential Recurso electrónico] edited by Vsevolod V Gurevich Servicio en línea New York [etc.] Springer New York [etc.] New York [etc.] Springer VIII, 447 p. 53 il., 42 il. en color VIII, 447 p. 53 il., 42 il. en color Handbook of Experimental Pharmacology 0171-2004 219 Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCRAgonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.-Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.-Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners Modo de acceso: Word Wide Web Modo de acceso: World Wide Web Springer (e-Books) Medicine Gene therapy Pharmacology Biochemistry Proteins Cell physiology Biomedicine Pharmacology/Toxicology Biochemistry, general Protein Structure Gene Therapy Cell Physiology Receptors Gurevich, Vsevolod V SpringerLink Books (Servicio en línea) Handbook of Experimental Pharmacology 0171-2004 219

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monografia Rebiun17471752 https://catalogo.rebiun.org/rebiun/record/Rebiun17471752 131128s2014 gw | s |||| 0|eng d 9783642411991 978-3-642-41199-1 9783642411984 10.1007/978-3-642-41199-1. doi UPNA0451643 UMA.RE Arrestins - Pharmacology and Therapeutic Potential Recurso electrónico] edited by Vsevolod V Gurevich Servicio en línea New York [etc.] Springer New York [etc.] New York [etc.] Springer VIII, 447 p. 53 il., 42 il. en color VIII, 447 p. 53 il., 42 il. en color Handbook of Experimental Pharmacology 0171-2004 219 Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCRAgonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.-Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.-Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners Modo de acceso: Word Wide Web Modo de acceso: World Wide Web Springer (e-Books) Medicine Gene therapy Pharmacology Biochemistry Proteins Cell physiology Biomedicine Pharmacology/Toxicology Biochemistry, general Protein Structure Gene Therapy Cell Physiology Receptors Gurevich, Vsevolod V SpringerLink Books (Servicio en línea) Handbook of Experimental Pharmacology 0171-2004 219