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Data mining in bioinformati...

Data mining in bioinformatics

Wang, Jason T. L.

Springer ©2005

8. 1. 1 Protein Subcellular Location The life sciences have entered the post-genome era where the focus of biologicalresearchhasshiftedfromgenomesequencestoproteinfunctionality. Withwhole-genomedraftsofmouseandhumaninhand, scientistsareputting more and more e?ort into obtaining information about the entire proteome in a given cell type. The properties of a protein include its amino acid sequences, its expression levels under various developmental stages and in di?erenttissues, its3Dstructureandactivesites, itsfunctionalandstructural binding partners, and its subcellular location. Protein subcellular location is important for understanding protein function inside the cell. For example, the observation that the product of a gene is localized in mitochondria will support the hypothesis that this protein or gene is involved in energy metabolism. Proteins localized in the cytoskeleton are probably involved in intracellular tra?cking and support. The context of protein functionality is well represented by protein subcellular location. Proteins have various subcellular location patterns [250]. One major category of proteins is synthesized on free ribosomes in the cytoplasm. Soluble proteins remain in the cytoplasm after their synthesis and function as small factories catalyzing cellular metabolites. Other proteins that have a target signal in their sequences are directed to their target organelle (such as mitochondria) via posttranslational transport through the organelle membrane. Nuclear proteins are transferred through pores on the nuclear envelope to the nucleus and mostly function as regulators. The second major category of proteins is synthesized on endoplasmic reticulum(ER)-associated ribosomes and passes through the reticuloendothelial system, consisting of the ER and the Golgi apparatus

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monografia Rebiun21577245 https://catalogo.rebiun.org/rebiun/record/Rebiun21577245 m o d cr cn||||||||| 081017s2005 enka ob 001 0 eng d 62713471 133156194 150332915 192060718 320967021 401410098 516040383 613457515 642461634 756420143 880015238 991954205 994766622 1005747281 1035708913 1044188617 1044307742 1044620908 1056333739 1056335101 1056393694 1058061838 1077847401 9781846280597 1846280591 1852336714 alk. paper) 9781852336714 alk. paper) 661029092X 9786610290925 10.1007/b138131 doi Springer eBook: Computer Science 978-1-85233-671-4 Springer http://www.springerlink.com GW5XE eng pn GW5XE OCLCQ CNTRU DEBBG AZU YNG UAB MNU CASUM E7B IDEBK OCLCQ N$T YDXCP TUU OCLCO EBLCP OCLCQ A7U OCLCQ OCLCF DEBSZ BEDGE OCLCQ SLY NLGGC COO NUI OCLCQ DGU Z5A PIFBR OTZ OCLCQ ESU OCLCQ VT2 OCLCO WY@ OCLCO OCLCA BUF OCLCO LUE OCLCO STF GILDS OCLCQ CEF U3W AU@ OCLCQ MERER ICG YOU CANPU QH lcco COM 082000 bisacsh Data mining in bioinformatics Jason T.L. Wang [and others] London Springer ©2005 London London Springer 1 online resource (xi, 340 pages) illustrations 1 online resource (xi, 340 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Advanced information and knowledge processing 1610-3947 Includes bibliographical references (pages 303-326) and index Overview -- to Data Mining in Bioinformatics -- Survey of Biodata Analysis from a Data Mining Perspective -- Sequence and Structure Alignment -- AntiClustAl: Multiple Sequence Alignment by Antipole Clustering -- RNA Structure Comparison and Alignment -- Biological Data Mining -- Piecewise Constant Modeling of Sequential Data Using Reversible Jump Markov Chain Monte Carlo -- Gene Mapping by Pattern Discovery -- Predicting Protein Folding Pathways -- Data Mining Methods for a Systematics of Protein Subcellular Location -- Mining Chemical Compounds -- Biological Data Management -- Phyloinformatics: Toward a Phylogenetic Database -- Declarative and Efficient Querying on Protein Secondary Structures -- Scalable Index Structures for Biological Data 8. 1. 1 Protein Subcellular Location The life sciences have entered the post-genome era where the focus of biologicalresearchhasshiftedfromgenomesequencestoproteinfunctionality. Withwhole-genomedraftsofmouseandhumaninhand, scientistsareputting more and more e?ort into obtaining information about the entire proteome in a given cell type. The properties of a protein include its amino acid sequences, its expression levels under various developmental stages and in di?erenttissues, its3Dstructureandactivesites, itsfunctionalandstructural binding partners, and its subcellular location. Protein subcellular location is important for understanding protein function inside the cell. For example, the observation that the product of a gene is localized in mitochondria will support the hypothesis that this protein or gene is involved in energy metabolism. Proteins localized in the cytoskeleton are probably involved in intracellular tra?cking and support. The context of protein functionality is well represented by protein subcellular location. Proteins have various subcellular location patterns [250]. One major category of proteins is synthesized on free ribosomes in the cytoplasm. Soluble proteins remain in the cytoplasm after their synthesis and function as small factories catalyzing cellular metabolites. Other proteins that have a target signal in their sequences are directed to their target organelle (such as mitochondria) via posttranslational transport through the organelle membrane. Nuclear proteins are transferred through pores on the nuclear envelope to the nucleus and mostly function as regulators. The second major category of proteins is synthesized on endoplasmic reticulum(ER)-associated ribosomes and passes through the reticuloendothelial system, consisting of the ER and the Golgi apparatus English Bioinformatics Data mining Bio-informatique Exploration de données (Informatique) COMPUTERS- Bioinformatics. Data mining Computational Biology- methods. Information Storage and Retrieval- methods. Bio-informatique. Exploration de données (Informatique) Bioinformatics. Informatique. Bioinformatics. Data mining Computational Biology- methods Information Storage and Retrieval- methods Electronic books Wang, Jason T. L. Springer e-books Springer e-books Print version Data mining in bioinformatics. London : Springer, ©2005 1852336714 9781852336714 (DLC) 2004048546 (OCoLC)55587153 Advanced information and knowledge processing. 1610-3947

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monografia Rebiun21577245 https://catalogo.rebiun.org/rebiun/record/Rebiun21577245 m o d cr cn||||||||| 081017s2005 enka ob 001 0 eng d 62713471 133156194 150332915 192060718 320967021 401410098 516040383 613457515 642461634 756420143 880015238 991954205 994766622 1005747281 1035708913 1044188617 1044307742 1044620908 1056333739 1056335101 1056393694 1058061838 1077847401 9781846280597 1846280591 1852336714 alk. paper) 9781852336714 alk. paper) 661029092X 9786610290925 10.1007/b138131 doi Springer eBook: Computer Science 978-1-85233-671-4 Springer http://www.springerlink.com GW5XE eng pn GW5XE OCLCQ CNTRU DEBBG AZU YNG UAB MNU CASUM E7B IDEBK OCLCQ N$T YDXCP TUU OCLCO EBLCP OCLCQ A7U OCLCQ OCLCF DEBSZ BEDGE OCLCQ SLY NLGGC COO NUI OCLCQ DGU Z5A PIFBR OTZ OCLCQ ESU OCLCQ VT2 OCLCO WY@ OCLCO OCLCA BUF OCLCO LUE OCLCO STF GILDS OCLCQ CEF U3W AU@ OCLCQ MERER ICG YOU CANPU QH lcco COM 082000 bisacsh Data mining in bioinformatics Jason T.L. Wang [and others] London Springer ©2005 London London Springer 1 online resource (xi, 340 pages) illustrations 1 online resource (xi, 340 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Advanced information and knowledge processing 1610-3947 Includes bibliographical references (pages 303-326) and index Overview -- to Data Mining in Bioinformatics -- Survey of Biodata Analysis from a Data Mining Perspective -- Sequence and Structure Alignment -- AntiClustAl: Multiple Sequence Alignment by Antipole Clustering -- RNA Structure Comparison and Alignment -- Biological Data Mining -- Piecewise Constant Modeling of Sequential Data Using Reversible Jump Markov Chain Monte Carlo -- Gene Mapping by Pattern Discovery -- Predicting Protein Folding Pathways -- Data Mining Methods for a Systematics of Protein Subcellular Location -- Mining Chemical Compounds -- Biological Data Management -- Phyloinformatics: Toward a Phylogenetic Database -- Declarative and Efficient Querying on Protein Secondary Structures -- Scalable Index Structures for Biological Data 8. 1. 1 Protein Subcellular Location The life sciences have entered the post-genome era where the focus of biologicalresearchhasshiftedfromgenomesequencestoproteinfunctionality. Withwhole-genomedraftsofmouseandhumaninhand, scientistsareputting more and more e?ort into obtaining information about the entire proteome in a given cell type. The properties of a protein include its amino acid sequences, its expression levels under various developmental stages and in di?erenttissues, its3Dstructureandactivesites, itsfunctionalandstructural binding partners, and its subcellular location. Protein subcellular location is important for understanding protein function inside the cell. For example, the observation that the product of a gene is localized in mitochondria will support the hypothesis that this protein or gene is involved in energy metabolism. Proteins localized in the cytoskeleton are probably involved in intracellular tra?cking and support. The context of protein functionality is well represented by protein subcellular location. Proteins have various subcellular location patterns [250]. One major category of proteins is synthesized on free ribosomes in the cytoplasm. Soluble proteins remain in the cytoplasm after their synthesis and function as small factories catalyzing cellular metabolites. Other proteins that have a target signal in their sequences are directed to their target organelle (such as mitochondria) via posttranslational transport through the organelle membrane. Nuclear proteins are transferred through pores on the nuclear envelope to the nucleus and mostly function as regulators. The second major category of proteins is synthesized on endoplasmic reticulum(ER)-associated ribosomes and passes through the reticuloendothelial system, consisting of the ER and the Golgi apparatus English Bioinformatics Data mining Bio-informatique Exploration de données (Informatique) COMPUTERS- Bioinformatics. Data mining Computational Biology- methods. Information Storage and Retrieval- methods. Bio-informatique. Exploration de données (Informatique) Bioinformatics. Informatique. Bioinformatics. Data mining Computational Biology- methods Information Storage and Retrieval- methods Electronic books Wang, Jason T. L. Springer e-books Springer e-books Print version Data mining in bioinformatics. London : Springer, ©2005 1852336714 9781852336714 (DLC) 2004048546 (OCoLC)55587153 Advanced information and knowledge processing. 1610-3947