Descripción del título
Epigenetic pathways in PTSD...
Epidemiological evidence supports a role for gene-environmental interactions in post-traumatic stress disorder (PTSD). Because environmental exposure to trauma is an etiological factor necessary for the development of PTSD, understanding the molecular mechanisms by which genes respond to traumatic stress may provide insight into the development and life-long persistence of PTSD symptoms. Emerging evidence suggests that DNA methylation, histone modifications, noncoding RNA regulation, and alternative splicing of mRNA provide an epigenetic means by which chronic stress and traumatic experiences alter gene expression to produce long-term changes in neuroanatomy, physiology and behavior. This research topic will focus on epigenetic components of PTSD, and highlight translational research including common measures and outcomes of stress and trauma found in animal, civilian and military research. We will also consider observational and epidemiologic studies that support epigenetic transmission of stress-related phenotypes. We aim to provide a forum for experts in the field to present novel research findings, methodology, opinions, hypotheses and critical reviews that address how traumatic stress interacts with the genome
Monografía
monografia Rebiun25400592 https://catalogo.rebiun.org/rebiun/record/Rebiun25400592 m o u cr#||||||||||| 160829s2015 sz a ob 000 | eng d 9782889193080 ebook) UPVA 998210824803706 UCAR 991007754654604213 CBUC 991009432602106719 CBUC 991004263257806713 CBUC 991013268021006708 CBUC 991010353831406709 CBUC 991000712368406712 PQKB UkMaJRU rda eng Epigenetic pathways in PTSD how traumatic experiences leave their signature on the genome topic editors Tania L. Roth, David M. Diamond and Karestan C. Koenen Switzerland Frontiers Media SA 2015 Switzerland Switzerland Frontiers Media SA 1 online resource (158 pages) illustrations, charts 1 online resource (158 pages) Frontiers Research Topics Bibliographic Level Mode of Issuance: Monograph Includes bibliographical references Open Access. Unrestricted online access star Epidemiological evidence supports a role for gene-environmental interactions in post-traumatic stress disorder (PTSD). Because environmental exposure to trauma is an etiological factor necessary for the development of PTSD, understanding the molecular mechanisms by which genes respond to traumatic stress may provide insight into the development and life-long persistence of PTSD symptoms. Emerging evidence suggests that DNA methylation, histone modifications, noncoding RNA regulation, and alternative splicing of mRNA provide an epigenetic means by which chronic stress and traumatic experiences alter gene expression to produce long-term changes in neuroanatomy, physiology and behavior. This research topic will focus on epigenetic components of PTSD, and highlight translational research including common measures and outcomes of stress and trauma found in animal, civilian and military research. We will also consider observational and epidemiologic studies that support epigenetic transmission of stress-related phenotypes. We aim to provide a forum for experts in the field to present novel research findings, methodology, opinions, hypotheses and critical reviews that address how traumatic stress interacts with the genome Mode of access: internet via World Wide Web English Koenen, Karestan C editor Diamond, David editor Roth, Tania L. editor