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Data-based radiation oncolo...
In radiation oncology as in many other specialties clinical trials are essential to investigate new therapy approaches. Usually, preparation for a prospective clinical trial is extremely time consuming until ethics approval is obtained. To test a new treatment usually many years pass before it can be implemented in the routine care. During that time, already new interventions emerge, new drugs appear on the market, technical & physical innovations are being implemented, novel biology driven concepts are translated into clinical approaches while we are still investigating the ones from years ago. Another problem is associated with molecular diagnostics and the growing amount of tumor specific biomarkers which allows for a better stratification of patient subgroups. On the other side, this may result in a much longer time for patient recruiting and consequently in larger multicenter trials. Moreover, all of the relevant data must be readily available for treatment decision making, treatment as well as follow-up, and ultimately for trial evaluation. This challenges even more for agreed standards in data acquisition, quality and management. How could we change the way currently clinical trials are performed in a way they are safe and ethically justifiable and speed up the initiation process, so we can provide new and better treatments faster for our patients? Further, while we rely on various quantitative information handling distributed, large heterogeneous amounts of data efficiently is very important. Thus data management becomes a strong focus. A good infrastructure helps to plan, tailor and conduct clinical trials in a way they are easy and quickly analyzable. In this research topic we want to discuss new ideas for intelligent trial designs and concepts for data management
Monografía
monografia Rebiun33937597 https://catalogo.rebiun.org/rebiun/record/Rebiun33937597 m o d cr|mn|---annan 202102s2018 xx |||||o ||| eneng d UPVA 998209136603706 UCAR 991008031617104213 CBUC 991000706143606712 CBUC 991004264679206713 CBUC 991009420568106719 CBUC 991010357618306709 CBUC 991013270843706708 eng 616.99/40642 23 Data-based radiation oncology design of clinical trials topic editors, Kerstin A. Kessel, Klinikum rechts der Isar, Technische Universität München, Helmholtz Zentrum München, Germany, Anne W. Lee, The University of Hong Kong Shenzhen Hospital, China, Sren M. Bentzen, University of Maryland, United States, Bhadrasain Vikram, National Cancer Institute (NIH), United States, Fridtjof Nuesslin, Klinikum rechts der Isar, Technische Universität München, Germany, Stephanie E. Combs, Klinikum rechts der Isar, Technische Universität München, Helmholtz Zentrum München, Germany Frontiers Media SA 2018 Frontiers Media SA 1 electronic resource (109 p.) 1 electronic resource (109 p.) Text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Unrestricted online access In radiation oncology as in many other specialties clinical trials are essential to investigate new therapy approaches. Usually, preparation for a prospective clinical trial is extremely time consuming until ethics approval is obtained. To test a new treatment usually many years pass before it can be implemented in the routine care. During that time, already new interventions emerge, new drugs appear on the market, technical & physical innovations are being implemented, novel biology driven concepts are translated into clinical approaches while we are still investigating the ones from years ago. Another problem is associated with molecular diagnostics and the growing amount of tumor specific biomarkers which allows for a better stratification of patient subgroups. On the other side, this may result in a much longer time for patient recruiting and consequently in larger multicenter trials. Moreover, all of the relevant data must be readily available for treatment decision making, treatment as well as follow-up, and ultimately for trial evaluation. This challenges even more for agreed standards in data acquisition, quality and management. How could we change the way currently clinical trials are performed in a way they are safe and ethically justifiable and speed up the initiation process, so we can provide new and better treatments faster for our patients? Further, while we rely on various quantitative information handling distributed, large heterogeneous amounts of data efficiently is very important. Thus data management becomes a strong focus. A good infrastructure helps to plan, tailor and conduct clinical trials in a way they are easy and quickly analyzable. In this research topic we want to discuss new ideas for intelligent trial designs and concepts for data management Creative Commons Attribution 4.0 International. CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode English Cáncer- Radiotherapy- Data processing Oncology, Experimental Study Management Clinical trials Data Collection Radiation Oncology Clinical Study design Bentzen, Sren M. editor Combs, S. E. Stephanie Elisabeth) editor Kessel, Kerstin A. 1984-) editor Lee, A. W. M. Anne W. M.) editor Nuesslin, Fridtjof editor Vikram, Bhadrasain editor 2-88945-438-X