Descripción del título
Molecular mechanisms of cel...
In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic potential of a cell is increased leading to the initiation and/or progression of tumourigenesis. Moreover, these genetic defects can increase or contribute to resistance to chemotherapeutic agents and/or radiotherapy. Modulating the outcome of cellular stress responses towards cell death in tumour cells without affecting surrounding normal cells is thus one of the ultimate aims in the development of new cancer therapeutics. To achieve this aim, a detailed understanding of cellular stress response pathways and their aberrations in cancer is required. This Research topic aims to reflect the broadness and complexity of this important area of cancer research. We encourage original studies, perspectives and review articles that relate to any aspect of cellular stress responses, from both a molecular and clinical perspective. Topics may include signal transduction pathways and genes/proteins regulating them; different stress stimuli (DNA damage, viruses, metabolic stress, hormones and others); cell cycle checkpoints, DNA repair, autophagy, apoptosis and other forms of cell death; mechanisms of resistance against cytotoxic drugs; novel strategies and drugs that interfere with cellular stress responses; and methods to study cellular stress responses. Articles that focus on a specific type of cancer with known characteristics related to cellular stress responses, for example melanoma or therapy-related cancers are also welcome
Monografía
monografia Rebiun27766573 https://catalogo.rebiun.org/rebiun/record/Rebiun27766573 m o u cr#c|#---||||| 160829s2015 fr a ob 000 0 eng d 9782889193080 ebook) UPVA 998211017003706 UCAR 991007754676104213 CBUC 991004262927606713 CBUC 991010356893806709 CBUC 991009428041106719 CBUC 991000703115906712 CBUC 991013268049506708 PQKB eng UkMaJRU rda eng Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications topic editors: Megan Chircop and Daniel Speidel France Frontiers Media SA 2015 France France Frontiers Media SA 1 online resource (159 pages) illustrations; digital, PDF file(s) 1 online resource (159 pages) Frontiers Research Topics Bibliographic Level Mode of Issuance: Monograph Includes bibliographical references Open Access. Unrestricted online access star In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic potential of a cell is increased leading to the initiation and/or progression of tumourigenesis. Moreover, these genetic defects can increase or contribute to resistance to chemotherapeutic agents and/or radiotherapy. Modulating the outcome of cellular stress responses towards cell death in tumour cells without affecting surrounding normal cells is thus one of the ultimate aims in the development of new cancer therapeutics. To achieve this aim, a detailed understanding of cellular stress response pathways and their aberrations in cancer is required. This Research topic aims to reflect the broadness and complexity of this important area of cancer research. We encourage original studies, perspectives and review articles that relate to any aspect of cellular stress responses, from both a molecular and clinical perspective. Topics may include signal transduction pathways and genes/proteins regulating them; different stress stimuli (DNA damage, viruses, metabolic stress, hormones and others); cell cycle checkpoints, DNA repair, autophagy, apoptosis and other forms of cell death; mechanisms of resistance against cytotoxic drugs; novel strategies and drugs that interfere with cellular stress responses; and methods to study cellular stress responses. Articles that focus on a specific type of cancer with known characteristics related to cellular stress responses, for example melanoma or therapy-related cancers are also welcome Mode of access: internet via World Wide Web English Speidel, Daniel editor Chircop, Megan editor