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Neuroinflammation in neuron...
Neuroinflammation has been implicated recently in the pathogenesis of many neurodegenerative diseases. The cross-talk between neurons and non-neuronal cells seems to be a critical step in the progression of neurodegeneration and molecules that have a beneficial role may turn into harmful players. Thus, matrix metalloproteinases (MMPs), which are involved in axonal growth and regeneration as well as synaptic plasticity, may also have detrimental effects. Recent evidence has linked MMPs to conditions like ischemia, multiple sclerosis, Alzheimer's disease and suggested that, together with their r
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monografia Rebiun19880837 https://catalogo.rebiun.org/rebiun/record/Rebiun19880837 m o d | cr -n--------- 070824s2007 ne af ob 001 0 eng d 2007298759 1-281-05695-2 9786611056957 0-08-055056-8 UPVA 997186268903706 CBUC 991013419494206708 CBUC 991010727577406709 MiAaPQ MiAaPQ MiAaPQ eng 616.8/047 Bagetta, Giacinto NEUROINFLAMMATION IN NEURONAL DEATH AND REPAIR Neuroinflammation in neuronal death and repair electronic resource] edited by Giacinto Bagetta, M. Tiziana Corasaniti, Stuart A. Lipton International Review of Neurobiology International Review of Neurobiology, Volume 82C Neuroinflammation in Neuronal Death and Repair , Volume 82C Amsterdam Boston Elsevier Academic Press c2007 Amsterdam Boston Amsterdam Boston Elsevier Academic Press 1 online resource (499 p.) 1 online resource (499 p.) Text txt computer c online resource cr International review of neurobiology v. 82 Description based upon print version of record Includes bibliographical references and index Front Cover; The Neuroinflammation in Neuronal Death and Repair; Copyright Page; Contents; Contributors; Preface; Foreword; Chapter 1: Inflammatory Mediators Leading to Protein Misfolding and Uncompetitive/Fast Off-Rate Drug Therapy for Neurodegenerative Disorders; I. Introduction; II. Protein Misfolding in Neurodegenerative Diseases; III. Generation of RNS/ROS; IV. Protein S-Nitrosylation and Neuronal Cell Death; V. Parkin and the UPS; VI. S-Nitrosylation and Parkin; VII. The Unfolded Protein Response and PDI VIII. S-Nitrosylation of PDI Mediates Protein Misfolding and Neurotoxicity in Cell Models of PD or ADIX. PDI Activity in ALS and Prion Disease; X. Potential Treatment of Excessive NMDA-Induced Ca2+ Influx and S-Nitrosylation; XI. Looking to the Future: NitroMemantines; XII. Conclusions; Acknowledgments; References; Chapter 2: Innate Immunity and Protective Neuroinflammation: New Emphasis on the Role of Neuroimmune Regulatory Proteins; I. Characteristics of the Cellular and Molecular Innate Immune Responses in the Brain; II. Innate Immune Response in Health: The Key Role of Physical Barriers III. Immunoprivileged Status of the Brain by Preventing the Infiltration of Potentially Harmful Systemic Immune Cells: Roles of ACAMPsIV. Protective Innate Immune Response During Brain Infection and Inflammation to Promote the Clearance of Pathogens: Roles of PAMPs; V. Interactions of Innate Immune Molecules with Toxic Proteins: Roles of PPAMPs; VI. Regulating the Innate Immune Response in the CNS While Promoting Tissue Repair: Roles of Neuroimmune Regulatory Molecules; VII. Innate Immunity and Neurogenesis; VIII. The Canonical Innate Immune System in the CNS: The Complement System IX. Conclusion: Elements to Drive Innate Immune Neuroprotective ActivitiesGlossary; References; Chapter 3: Glutamate Release from Astrocytes in Physiological Conditions and in Neurodegenerative Disorders Characterized by Neuroinflammation; I. Introduction; II. Ca2+-Dependent Glutamate Release from Astrocytes; III. Excitotoxicity Involving Ca2+-Dependent Glutamate Release from Astrocytes in Pathological Conditions: The Case of ADC; IV. Astrocytic Alterations and Ca2+-Dependent Glutamate Release Dysfunction in AD; V. Conclusions; References Chapter 4: The High-Mobility Group Box 1 Cytokine Induces Transporter-Mediated Release of Glutamate from Glial Subcellular Particles (Gliosomes) Prepared from in Situ-Matured AstrocytesI. Introduction; II. Gliosomes as a Model to Study Astrocyte Characteristics; A. Characterization of the Gliosome Preparation; B. Glutamate Release in Gliosomes; C. Expression of Proteins of the Release Machinery in Gliosomes; III. HMGB1-Induced Glutamate Release from Gliosomes; A. Cytokine Properties of HMGB1; B. Effect of HMGB1 on Glutamate Release from Gliosomes and Synaptosomes C. Mechanisms of the HMGB1-Induced Release of Glutamate from Gliosomes Neuroinflammation has been implicated recently in the pathogenesis of many neurodegenerative diseases. The cross-talk between neurons and non-neuronal cells seems to be a critical step in the progression of neurodegeneration and molecules that have a beneficial role may turn into harmful players. Thus, matrix metalloproteinases (MMPs), which are involved in axonal growth and regeneration as well as synaptic plasticity, may also have detrimental effects. Recent evidence has linked MMPs to conditions like ischemia, multiple sclerosis, Alzheimer's disease and suggested that, together with their r English Nervous system- Degeneration Nervous system- Diseases Neurobiology Inflammation Electronic books Bagetta, Giacinto Corasaniti, M. Tiziana Lipton, Stuart A. International review of neurobiology (CKB)954926958890 (DLC)2011200620 (OCoLC)61847738 2162-5514 0-12-373989-6 International review of neurobiology v. 82